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Mapk1tm1Gela
Targeted Allele Detail
Summary
Symbol: Mapk1tm1Gela
Name: mitogen-activated protein kinase 1; targeted mutation 1, Gary E Landreth
MGI ID: MGI:3803954
Synonyms: ERK2fl, Mapk1flox
Gene: Mapk1  Location: Chr16:16801246-16865317 bp, + strand  Genetic Position: Chr16, 10.53 cM
Alliance: Mapk1tm1Gela page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:137882
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was inserted upstream of exon 2 and an additional loxP site was inserted downstream of exon 2. Transient cre transfection into ES cells was used to remove the neo cassette leaving exon 2 floxed. (J:137882)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 16 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Mapk1tm1Gela
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk1 Mutation:  34 strains or lines available
References
Original:  J:137882 Samuels IS, et al., Deletion of ERK2 mitogen-activated protein kinase identifies its key roles in cortical neurogenesis and cognitive function. J Neurosci. 2008 Jul 2;28(27):6983-95
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory