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Targeted Allele Detail
Symbol: Fgfr2tm1Dor
Name: fibroblast growth factor receptor 2; targeted mutation 1, David M Ornitz
MGI ID: MGI:3044679
Synonyms: Fgfr2delta8-10lox, Fgfr2f, Fgfr2fl, Fgfr2flox, Fgfr2Lox, Fgfr2loxP
Gene: Fgfr2  Location: Chr7:129764181-129868538 bp, - strand  Genetic Position: Chr7, 73.19 cM
Alliance: Fgfr2tm1Dor page
Germline Transmission:  Earliest citation of germline transmission: J:90391
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExons 8 through 10 were flanked by a single loxP site in intron 7 and an FRT-flanked neo cassette with a 3' loxP site in intron 10. (J:90391)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 129 assay results
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  70 strains or lines available
Original:  J:90391 Yu K, et al., Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth. Development. 2003 Jul;130(13):3063-74
All:  155 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory