Men1^tm1.2Ctre
Targeted Allele Detail

Summary

• Symbol: Men1^tm1.2Ctre
• Name: multiple endocrine neoplasia 1; targeted mutation 1.2, Judy S Crabtree
• MGI ID: MGI:2683274
• Synonyms: deltaN, ΔN, dN, Men1^deltaN, Men1^ΔN, Men1dN, Men1^fl
• Gene: Men1 Location: Chr19:6385009-6390921 bp, + strand Genetic Position: Chr19, 4.45 cM, cytoband A
• Alliance: Men1^tm1.2Ctre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86642
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 3 through 8 are flanked by single loxP sites in introns 2 and 8. This allele was generated by removing the floxed neo cassette from Men1^tm1Ctre via cre-mediated recombination. (J:86642)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Men1^tm1.2Ctre

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Men1 Mutation: 40 strains or lines available

Notes

Phenotypic Similarity to Human Syndrome: Hyperparathyroidism J:86642.

References

• Original: J:86642 Libutti SK, et al., Parathyroid gland-specific deletion of the mouse Men1 gene results in parathyroid neoplasia and hypercalcemic hyperparathyroidism. Cancer Res. 2003 Nov 15;63(22):8022-8
• All: 15 reference(s)