Flna^tm1.1Caw
Targeted Allele Detail

Summary

• Symbol: Flna^tm1.1Caw
• Name: filamin, alpha; targeted mutation 1.1, Christopher A Walsh
• MGI ID: MGI:3699305
• Synonyms: Flna^c, FlnA^loxP
• Gene: Flna Location: ChrX:73267067-73293426 bp, - strand Genetic Position: ChrX, 37.89 cM
• Alliance: Flna^tm1.1Caw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:118252
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A combination of homologous recombination and transient cre expression resulted in the flanking of exons 3-7 with loxP sites. (J:118252)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Flna Mutation: 18 strains or lines available

References

• Original: J:118252 Feng Y, et al., Filamin A (FLNA) is required for cell-cell contact in vascular development and cardiac morphogenesis. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19836-41
• All: 23 reference(s)