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Krastm4Tyj
Targeted Allele Detail
Summary
Symbol: Krastm4Tyj
Name: Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
MGI ID: MGI:2429948
Synonyms: caKRas, KR, Kras2tm14Tyj, Kras2tm4Tyj, KrasG12D, K-RasG12D, K-Ras(G12D)fl, K-RasL, KrasLox, K-rasLSL, KrasLSL-G12D, Lox-Stop-Lox-KrasG12D, LSL-KrasG12D, LSL-K-rasG12D, LSL-K-ras G12D, LSL-KrasG12D, LSL-Kras G12D
Gene: Kras  Location: Chr6:145162425-145195965 bp, - strand  Genetic Position: Chr6, 77.37 cM, cytoband G2
Alliance: Krastm4Tyj page
Pancreatic tumors in Krastm4Tyj/Krastm4Tyj Trim33tm1Los/Trim33tm1Los Tg(Pdx1-cre)89.1Dam/0 and Krastm4Tyj/Krastm4Tyj Cdkn2atm4Rdp/Cdkn2atm4Rdp Tg(Pdx1-cre)89.1Dam/0 mice

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:73445
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout)
Mutations:    Insertion, Single point mutation
 
Mutation detailsGlycine codon 12 was changed to aspartic acid (p.G12D) to encode an oncogenic form of the KRAS2 protein. A loxP site flanked STOP cassette was included upstream of the inserted Kras2 sequence, such that the mutant transcript would be expressed only after Cre-mediated recombination. (J:73445)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 67 assay results
12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 52 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Krastm4Tyj
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Kras Mutation:  76 strains or lines available
References
Original:  J:73445 Jackson EL, et al., Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras. Genes Dev. 2001 Dec 15;15(24):3243-8
All:  1417 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory