About   Help   FAQ
Phenotype Image Detail
Image
Caption Homozygous deletion of Trim33 (Tif1gamma) cooperates with activated KrasG12D mutation to induce cystic tumors of the pancreas in Krastm4Tyj/Krastm4Tyj Trim33tm1Los/Trim33tm1Los Tg(Pdx1-cre)89.1Dam/0 (Pdx1-cre;LSL-KrasG12D;Tif1gammalox/lox) mice. Homozgyous deletion of Cdkn2a cooperates with activated KrasG12D mutation to induce solid tumors in Krastm4Tyj/Krastm4Tyj Cdkn2atm4Rdp/Cdkn2atm4Rdp Tg(Pdx1-cre)89.1Dam/0 (Pdx1-Cre;LSL-KrasG12D;Ink4A/Arflox/lox). Magnetic Resonance Imaging (MRI) (A-C). Positron Emission Tomography (PET) (D-F). Gross anatomy of the pancreas after dissection (G-I). Hematoxylin Phloxine Saffron (HPS) staining of pancreas sections (J-L). Acinar tissue (stars), scattered endocrine islets (arrow) and exocrine ducts (arrowhead). When notified, pancreas is circled in red dashed lines. Pdx1-cre;LSL-KrasG12D;Tif1gammalox/lox mice used in this experiment were 154 days old and representative of the 4 mice we analyzed at the age of 18-27 weeks.
Copyright This image is from Vincent DF, PLoS Genet 2009 Jul;5(7):e1000575, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:151781
Associated
Alleles
Symbol Name
Cdkn2atm4Rdp cyclin dependent kinase inhibitor 2A; targeted mutation 4, Ronald DePinho
Krastm4Tyj Kirsten rat sarcoma viral oncogene homolog; targeted mutation 4, Tyler Jacks
Tg(Pdx1-cre)89.1Dam transgene insertion 89.1, Douglas A Melton
Trim33tm1Los tripartite motif-containing 33; targeted mutation 1, Regine Losson
Associated
Genotypes
Allelic Composition Genetic Background
Krastm4Tyj/Krastm4Tyj
Trim33tm1Los/Trim33tm1Los
Tg(Pdx1-cre)89.1Dam/0
involves: 129S2/SvPas * 129S4/SvJae * C57BL/6 * DBA/2
Cdkn2atm4Rdp/Cdkn2atm4Rdp
Krastm4Tyj/Krastm4Tyj
Tg(Pdx1-cre)89.1Dam/0
involves: 129S4/SvJae * C57BL/6 * DBA/2

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
07/05/2024
MGI 6.24
The Jackson Laboratory