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Ctnnb1tm1Mmt
Targeted Allele Detail
Summary
Symbol: Ctnnb1tm1Mmt
Name: catenin beta 1; targeted mutation 1, Makoto M Taketo
MGI ID: MGI:1858008
Synonyms: B-cateninfl3, BcatGOF, beta-catact, beta-catc.a., beta-catenindeltaex3, beta-cateninlox-ex3, beta-cateninloxEx3, beta-catenin/loxP(ex3), beta-catex3, beta-catgof, beta-catloxEx3, Catnb(ex3)fl, Catnb(Flox3, Catnblox(ex3), Catnbtm1Tak, Ctnnb1ex3, Ctnnb1(Ex3)fl, Ctnnb1ex3(loxP), Ctnnb1f(Ex3), Ctnnb1fl(ex3), Ctnnb1flx(ex3), Ctnnb1iGOF, Ctnnb1lox(ex3), Ctnnbllox(ex3), Ctnnblox(ex3), GOF
Gene: Ctnnb1  Location: Chr9:120762466-120789573 bp, + strand  Genetic Position: Chr9, 72.19 cM
Alliance: Ctnnb1tm1Mmt page
Kidney agenesis in Ctnnb1tm1Mmt/Ctnnb1+ Tg(Hoxb7-cre)13Amc/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58367
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsInsertion of a PGK-neomycin resistance cassette introduced two loxP sites flanking exon 3 and the inserted cassette. Exon 3 contains phosphorylation target serine/threonine residues. Future deletion of exon 3 with cre recombinase would result in mRNA whose exons 2 and 4 are connected in frame. (J:58367)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 320 assay results
12 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 47 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Ctnnb1tm1Mmt
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ctnnb1 Mutation:  48 strains or lines available
References
Original:  J:58367 Harada N, et al., Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 1999 Nov 1;18(21):5931-42
All:  528 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory