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| Caption | Heparan sulfate deficiency causes craniofacial malformation. Stereomicroscopy for control embryos (A, C, E, and G) and Ext1tm1Yama/Ext1tm1Yama H2az2Tg(Wnt1-cre)11Rth/0 embryos (B, D, F, H, and I) at E18.5. The mutant embryos showed ear deformity (black arrow in B), severe cleft palate (white arrows in B and D), and the lack of a hard palate (open arrow in F). The eyes of mutants also displayed eyelid defects (black arrowheads) and iris coloboma (white arrowhead in H). Some colobomas affected both the iris and ciliary body (white arrowhead in I). Original magnification, 3.2 (G-I). | ||||||
| Copyright | This image is from Iwao K, J Clin Invest 2009 Jul;119(7):1997-2008 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:152572 | ||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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