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Targeted Allele Detail
Symbol: Stk11tm1.1Rdp
Name: serine/threonine kinase 11; targeted mutation 1.1, Ronald DePinho
MGI ID: MGI:2387402
Synonyms: Lkb1L, Lkb1lox
Gene: Stk11  Location: Chr10:79951637-79966516 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Stk11tm1.1Rdp page
Germline Transmission:  Earliest citation of germline transmission: J:78818
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsThe frt flanked neo cassette was excised from intron 2 of Stk11tm1Rdp by the in vivo expression of flp recombinase. Exons 3 through 6 were left flanked by single loxP sites in introns 2 and 6. (J:78818)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 37 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Stk11tm1.1Rdp
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Stk11 Mutation:  23 strains or lines available
Original:  J:78818 Bardeesy N, et al., Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12;419(6903):162-7
All:  108 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory