Hdac8^tm1.1Eno
Targeted Allele Detail

Summary

• Symbol: Hdac8^tm1.1Eno
• Name: histone deacetylase 8; targeted mutation 1.1, Eric N Olson
• MGI ID: MGI:3851814
• Synonyms: Hdac8^loxP
• Gene: Hdac8 Location: ChrX:101328245-101548965 bp, - strand Genetic Position: ChrX, 45.28 cM, cytoband C3
• Alliance: Hdac8^tm1.1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:150709
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around exon 4 with a Frt-flanked neomycin cassette included between the exon and the downstream loxP site. Chimeric mice were bred with Flpe transgenic mice to remove the neomycin cassette, leaving exon 4 floxed. Cre-mediated deletion of exon 4 will eliminate part of the catalytic domain of the protein product and will also result in a frame shift upon fusion of exon 3 to exon 5. (J:150709)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac8 Mutation: 8 strains or lines available

References

• Original: J:150709 Haberland M, et al., Epigenetic control of skull morphogenesis by histone deacetylase 8. Genes Dev. 2009 Jul 15;23(14):1625-30
• All: 4 reference(s)