Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Hdac8tm1.1Eno mutation
(0 available);
any
Hdac8 mutation
(8 available)
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mortality/aging
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• some mice die within 4-6 hours after birth from brain hemorrhaging
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cardiovascular system
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• some mice die within 4-6 hours after birth from brain hemorrhaging
• hemorrhaging results from ossification defects in the skull
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craniofacial
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• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone
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nervous system
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• some mice die within 4-6 hours after birth from brain hemorrhaging
• hemorrhaging results from ossification defects in the skull
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skeleton
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• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone
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• ossification defects lead to the presence of soft tissues in the frontal and interparietal bone and incomplete skull closure
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation
(0 available);
any
Hdac8 mutation
(8 available)
Tg(Col1a1-cre)1Kry mutation
(2 available)
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normal phenotype
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• no abnormal phenotype is detected in skull development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation
(0 available);
any
Hdac8 mutation
(8 available)
Tg(Col2a1-cre)1Bhr mutation
(3 available)
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normal phenotype
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• no abnormal phenotype is detected in skull development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation
(0 available);
any
Hdac8 mutation
(8 available)
Twist2tm1(cre)Dor mutation
(0 available);
any
Twist2 mutation
(10 available)
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normal phenotype
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• no abnormal phenotype is detected in skull development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation
(0 available);
any
Hdac8 mutation
(8 available)
Tg(Zp3-cre)93Knw mutation
(2 available)
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reproductive system
 N |
• females exhibit normal ovarian histology and follicle counts at 18 days (prepubertal), at 7 weeks, and at 7 months of age, indicating normal folliculogenesis
• when bred with wild type male mice for 6 months, adult females show normal fertility with no significant differences in average litter size or age-associated changes in fertility relative to controls
• fully grown oocytes from hyperstimulated female mice exhibit no changes in oocyte number, germinal vesicle diameter, and nuclear or nucleolar morphology
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac8tm1.1Eno mutation
(0 available);
any
Hdac8 mutation
(8 available)
Hdac8tm1.2Eno mutation
(0 available);
any
Hdac8 mutation
(8 available)
Tg(Ddx4-cre)1Dcas mutation
(2 available)
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reproductive system
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N |
• females exhibit normal ovarian histology and follicle counts at 18 days (prepubertal) and at 7 months of age, indicating normal folliculogenesis
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• reduced female fertility is likely due to subtle defects in oogenesis resulting in smaller oocytes with compromised cytoplasmic competence
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• fully grown oocytes from hyperstimulated females are significantly smaller than control oocytes, as determined by germinal vesicle diameter
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• in vitro oocyte maturation (IVM) analysis revealed that only 80% of germinal vesicle-intact oocytes arrested in prophase of meiosis I are able to resume meiosis and reach metaphase of meiosis I (MI) within 8 h relative to ~90% in controls
• however, spindle morphology and chromosome alignment are normal at the MI stage and no chromosome segregation defects are observed following IVM
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• females show a mild subfertility phenotype
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• when bred with wild type male mice for 6 months, adult females produce a significantly lower average litter size than controls
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cellular
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• reduced female fertility is likely due to subtle defects in oogenesis resulting in smaller oocytes with compromised cytoplasmic competence
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• fully grown oocytes from hyperstimulated females are significantly smaller than control oocytes, as determined by germinal vesicle diameter
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• in vitro oocyte maturation (IVM) analysis revealed that only 80% of germinal vesicle-intact oocytes arrested in prophase of meiosis I are able to resume meiosis and reach metaphase of meiosis I (MI) within 8 h relative to ~90% in controls
• however, spindle morphology and chromosome alignment are normal at the MI stage and no chromosome segregation defects are observed following IVM
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embryo
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N |
• in culture, the % of zygotes progressing to the blastocyst stage is not significantly different from that in controls, suggesting normal preimplantation embryo development
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Analysis Tools