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Bmp7tm1.1Dgra
Targeted Allele Detail
Summary
Symbol: Bmp7tm1.1Dgra
Name: bone morphogenetic protein 7; targeted mutation 1.1, Daniel Graf
MGI ID: MGI:3847797
Synonyms: Bmp7fl, Bmp7flx, Bmp7flx(neo-)
Gene: Bmp7  Location: Chr2:172709805-172782114 bp, - strand  Genetic Position: Chr2, 95.54 cM
Alliance: Bmp7tm1.1Dgra page
Abnormal caudal body formation in Bmp4tm4Blh/Bmp4+ Bmp7tm1.1Dgra/Bmp7tm1.1Dgra Hoxa3tm1(cre)Moon/Hoxa3+ embryos

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:149134
Parent Cell Line:  F1H4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NTac)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and an frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Germ line, frt mediated recombination was used to remove the neo cassette leaving exon 1 floxed. (J:149134)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bmp7 Mutation:  37 strains or lines available
References
Original:  J:149134 Zouvelou V, et al., Generation and functional characterization of mice with a conditional BMP7 allele. Int J Dev Biol. 2009;53(4):597-603
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory