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Bmp7 Gene Detail
Summary
  • Symbol
    Bmp7
  • Name
    bone morphogenetic protein 7
  • Synonyms
    OP1, osteogenic protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103302
    NCBI Gene: 12162
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:172709805-172782114 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 95.54 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    600 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103302
 protein coding gene Chr2:172709805-172782114 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026949
 protein coding gene Chr2:179105849-179178175 (-)
A/J MGP_AJ_G0026916
 protein coding gene Chr2:171573605-171646019 (-)
AKR/J MGP_AKRJ_G0026887
 protein coding gene Chr2:176749083-176821469 (-)
BALB/cJ MGP_BALBcJ_G0026925
 protein coding gene Chr2:171974305-172046591 (-)
C3H/HeJ MGP_C3HHeJ_G0026667
 protein coding gene Chr2:177130901-177204353 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027372
 protein coding gene Chr2:184258227-184332514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024742
 protein coding gene Chr2:164814974-164889374 (-)
CAST/EiJ MGP_CASTEiJ_G0026125
 protein coding gene Chr2:177826283-177899973 (-)
CBA/J MGP_CBAJ_G0026644
 protein coding gene Chr2:191162541-191240987 (-)
DBA/2J MGP_DBA2J_G0026782
 protein coding gene Chr2:170672445-170744441 (-)
FVB/NJ MGP_FVBNJ_G0026748
 protein coding gene Chr2:169285395-169360436 (-)
LP/J MGP_LPJ_G0026883
 protein coding gene Chr2:179036730-179116310 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026767
 protein coding gene Chr2:194109763-194184215 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027429
 protein coding gene Chr2:176752710-176829718 (-)
PWK/PhJ MGP_PWKPhJ_G0025862
 protein coding gene Chr2:170459822-170535139 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025662
 protein coding gene Chr2:175742019-175816803 (-)
WSB/EiJ MGP_WSBEiJ_G0026198
 protein coding gene Chr2:177717299-177792154 (-)



Homology
more
  • Human Ortholog
    BMP7, bone morphogenetic protein 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BMP7, bone morphogenetic protein 7
  • Synonyms
    OP-1
  • Links
    NCBI Gene ID: 655
    neXtProt AC: NX_P18075
    UniProt: P18075

  • Chr Location
    20q13.31; chr20:57168753-57266641 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Bmp7 mouse models; 1 with human BMP7 associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    105 phenotypes from 9 alleles in 11 genetic backgrounds
    90 phenotypes from multigenic genotypes
    2 images
    95 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Various homozygous targeted mutations result in postnatal lethality, a wide range of skeletal and cartilage abnormalities, renal dysplasia and polycystic kidney, and eye defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    115
  • GO References
    31
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1899
  • Tissues
    612
  • cDNA Data
    33
  • Literature Summary
    349
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12162 NCBI Gene Model | MGI Sequence Detail 72310 C57BL/6J ±  kb
    transcript NM_007557 RefSeq | MGI Sequence Detail 3670 ZRU/MplStud  
    polypeptide P23359 UniProt | EBI | MGI Sequence Detail 430 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      Genomic 4
      cDNA 41
      Primer pair 20
      Other 34

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-24186
    References
    more
    • Summaries
      All 481
      Developmental Gene Expression 349
      Diseases 2
      Gene Ontology 31
      Phenotypes 95
    • Earliest
      J:148755 Burgoyne PS, et al., XY follicle cells in ovaries of XX----XY female mouse chimaeras. Development. 1988 Dec;104(4):683-8
    • Latest
      J:339774 Yang H, et al., Omentin-1 drives cardiomyocyte cell cycle arrest and metabolic maturation by interacting with BMP7. Cell Mol Life Sci. 2023 Jun 21;80(7):186
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory