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Phenotypes Associated with This Genotype
Genotype
MGI:5642218
Allelic
Composition
Bmp7tm1.1Dgra/Bmp7tm1.1Dgra
Tg(Prrx1-cre)1Cjt/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp7tm1.1Dgra mutation (0 available); any Bmp7 mutation (37 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• slight increase in accumulation of F4/80+ macrophages in the synovial membrane at 4 weeks of age which increases significantly with age, indicating sinovits
• mice show articular cartilage degeneration after 8 weeks of age

skeleton
• slight increase in accumulation of F4/80+ macrophages in the synovial membrane at 4 weeks of age which increases significantly with age, indicating sinovits
• mice show articular cartilage degeneration after 8 weeks of age
• loss of proteoglycan and aggrecan content in articular cartilage at 8 weeks of age which is severe at 24 weeks
• extensive synovial hyperplasia at 8 and 24 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoarthritis DOID:8398 J:221175


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory