osteoarthritis Disease Ontology Browser

Disease Ontology Browser

osteoarthritis (DOID:8398)
Alliance: disease page
Synonyms: degenerative arthritis; degenerative joint disease; hypertrophic arthritis; osteoarthrosis; Osteoarthrosis and allied disorder
Alt IDs: ICD9CM:715.3, UMLS_CUI:C0157946
Definition: An arthritis that has_material_basis_in worn out cartilage located_in joint.

Term Browser
Genes (42)
Models (15)

Disease References using Mouse Models (21)

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Gdf5

Allelic Composition	Genetic Background	Reference	Phenotypes
Gdf5Rgsc451/Gdf5Rgsc451	C57BL/6JJcl-Gdf5^Rgsc451	J:125122	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Matn3

Allelic Composition	Genetic Background	Reference	Phenotypes
Matn3tm1Brd/Matn3tm1Brd	involves: 129S7/SvEvBrd * C57BL/6	J:112002	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Atp7a

Allelic Composition	Genetic Background	Reference	Phenotypes
Atp7aMo-blo/Y	B6.Cg-Atp7a^Mo-blo/J	J:36378	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Bmp7

Allelic Composition	Genetic Background	Reference	Phenotypes
Bmp7tm1.1Dgra/Bmp7tm1.1Dgra Tg(Prrx1-cre)1Cjt/0	involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J	J:221175	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Bmpr1a

Allelic Composition	Genetic Background	Reference	Phenotypes
Bmpr1atm2.1Bhr/Bmpr1atm2.2Bhr Tg(Gdf5-cre,-ALPP)1Kng/0	involves: 129 * C57BL/6 * FVB/N-Tg(Gdf5-cre-ALPP)1Kng	J:97780	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Col9a1

Allelic Composition	Genetic Background	Reference	Phenotypes
Col9a1tm1Jae/Col9a1tm1Jae	involves: 129S2/SvPas	J:117910	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Col11a1

Allelic Composition	Genetic Background	Reference	Phenotypes
Col11a1cho/Col11a1+	involves: C57BL/6Fr	J:106282	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Enpp1

Allelic Composition	Genetic Background	Reference	Phenotypes
Enpp1ttw/Enpp1ttw	involves: ICR	J:37369, J:19124	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Erg

Allelic Composition	Genetic Background	Reference	Phenotypes
Ergtm1.1Iwamo/Ergtm1.1Iwamo Tg(Gdf5-cre,-ALPP)1Kng/?	involves: 129S4/SvJaeSor * C57BL/6 * FVB/N	J:243715	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Errfi1

Allelic Composition	Genetic Background	Reference	Phenotypes
Errfi1tm1Gvw/Errfi1tm1Gvw	Not Specified	J:100927	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Myl3

Allelic Composition	Genetic Background	Reference	Phenotypes
Myl3tm1a(EUCOMM)Hmgu/Myl3tm1a(EUCOMM)Hmgu Tg(Col2a1-cre)1Xya/0	involves: C57BL/6J * C57BL/6N	J:343166	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Smad3

Allelic Composition	Genetic Background	Reference	Phenotypes
Smad3tm1Cxd/Smad3tm1Cxd	involves: 129S6/SvEvTac	J:68792	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Gene: Tgfbr1

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(Col2a1-cre/ERT2)1Dic/0 Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl	involves: 129 * C57BL/6	J:271724	View

Mouse Models

Human Disease Modeled: osteoarthritis
Associated Mouse Transgene: Tg(MT2A-TGFBR2)4Rser

Allelic Composition	Genetic Background	Reference	Phenotypes
Tg(MT2A-TGFBR2)4Rser/0	involves: C57BL/6 * DBA	J:44579	View

Mouse Models

Human Disease Modeled: osteoarthritis

Allelic Composition	Genetic Background	Reference	Phenotypes
Bgntm1Mfy/Y Fmodtm1Aol/Fmodtm1Aol	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ	J:112779, J:117908	View

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23