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Targeted Allele Detail
Symbol: Bgntm1Mfy
Name: biglycan; targeted mutation 1, Marian F Young
MGI ID: MGI:2153057
Synonyms: Bgn-/0, Bgn0, bgn-KO
Gene: Bgn  Location: ChrX:72527208-72539539 bp, + strand  Genetic Position: ChrX, 37.33 cM, cytoband B
Alliance: Bgntm1Mfy page
Germline Transmission:  Earliest citation of germline transmission: J:49647
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that no transcript was detectable in hemizyogous male mice and western blot analysis showed that the protein was not expressed in hemizygous male mice. (J:49647)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Bgn Mutation:  8 strains or lines available
Original:  J:49647 Xu T, et al., Targeted disruption of the biglycan gene leads to an osteoporosis-like phenotype in mice. Nat Genet. 1998 Sep;20(1):78-82
All:  65 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory