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Phenotypes Associated with This Genotype
Genotype
MGI:3687322
Allelic
Composition
Matn3tm1Brd/Matn3tm1Brd
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Matn3tm1Brd mutation (0 available); any Matn3 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• rare in knee cartilage at 18 weeks of age
• present in 100% of year old mice as opposed to 45% of controls who also suffer from less severe symptoms
• hypertrophic zone of the proximal growth plate of tibia expanded 47% relative to controls at E16.5 and E17.5
• expansion attenuated during perinatal development and becomes normal in newborns
• chondrocytes in proximal growth plate exit the cell cycle early
• at E16.5, chondrocytes undergo premature differentiation to hypertrophic stage
• whole body bone mass density measurements significantly elevated by 18 weeks of age
• bone mass density measurements for the knee joint are elevated by 7 weeks of age

immune system
• rare in knee cartilage at 18 weeks of age
• present in 100% of year old mice as opposed to 45% of controls who also suffer from less severe symptoms

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoarthritis DOID:8398 J:112002


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory