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Phenotypes Associated with This Genotype
Genotype
MGI:7578779
Allelic
Composition
Myl3tm1a(EUCOMM)Hmgu/Myl3tm1a(EUCOMM)Hmgu
Tg(Col2a1-cre)1Xya/0
Genetic
Background
involves: C57BL/6J * C57BL/6N
Cell Lines HEPD0622_5_G02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl3tm1a(EUCOMM)Hmgu mutation (0 available); any Myl3 mutation (20 available)
Tg(Col2a1-cre)1Xya mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 6-month-old mice exhibit cartilage destruction which becomes severe at 18 months of age indicating spontaneous age-related osteoarthritis
• cartilage destruction is accompanied by aggravated synovial inflammation but comparable osteophyte maturity as in controls
• expression of senescence, DNA damage, and catabolic markers are decreased in cartilage of aged mice
• however, mice exhibit normal skeletal development, with normal organization of growth plates and normal body weight

skeleton
• 6-month-old mice exhibit cartilage destruction which becomes severe at 18 months of age indicating spontaneous age-related osteoarthritis
• cartilage destruction is accompanied by aggravated synovial inflammation but comparable osteophyte maturity as in controls
• expression of senescence, DNA damage, and catabolic markers are decreased in cartilage of aged mice
• however, mice exhibit normal skeletal development, with normal organization of growth plates and normal body weight
• marker analysis indicates enhanced cellular senescence of chondrocytes

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoarthritis DOID:8398 J:343166


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory