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Phenotypes Associated with This Genotype
Genotype
MGI:3793864
Allelic
Composition
Atp7aMo-blo/Y
Genetic
Background
B6.Cg-Atp7aMo-blo/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7aMo-blo mutation (3 available); any Atp7a mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• at 2-4 months of age, femoral-tibial joints show structural and cellular changes correlating with mild to moderate osteoarthritis; changes increase in severity with age
• at 10 months, loss of integrity of weight bearing regions of the joints is detected, with cellular changes including cloning and cell loss
• 2 month-old mice show decreased collagen crosslinks in cartilage compared to wild-type
• lesions such as defects in cartilage integrity are observed in joints at 10 months of age

immune system
• at 2-4 months of age, femoral-tibial joints show structural and cellular changes correlating with mild to moderate osteoarthritis; changes increase in severity with age
• at 10 months, loss of integrity of weight bearing regions of the joints is detected, with cellular changes including cloning and cell loss

cellular
• vascular superoxide anion production is increased in all layers of aortas in mutants compared to controls

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteoarthritis DOID:8398 J:36378


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory