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Transgene Detail
Symbol: Tg(MT2A-TGFBR2)4Rser
Name: transgene insertion 4, Rosa Serra
MGI ID: MGI:3620964
Synonyms: MT-DNIIR-4, MTR4
Transgene: Tg(MT2A-TGFBR2)4Rser  Location: unknown  
Alliance: Tg(MT2A-TGFBR2)4Rser page
Strain of Origin:  (C57BL/6 x DBA)F1
Transgene Type:    Transgenic (Dominant negative, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(MT2A-TGFBR2)4Rser expresses 1 gene
Mutation detailsThe transgene contains a truncated human TGFBR2 gene under the control of the human MT2A promoter. The truncated receptor contains the extracellular, transmembrane, and juxtamembrane domains. Most of the cytoplasmic domain including the kinase domain is deleted. This mutant receptor acts as a dominant-negative mutation. The promoter contains four metal responsive elements and a beta-globin TATA element, splice sites, and polyadenylation signal. Five lines, 4, 15, 27, 28, and 30, were generated. (J:44579)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 15 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Original:  J:44579 Serra R, et al., Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis. J Cell Biol. 1997 Oct 20;139(2):541-52
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory