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Smad3tm1Cxd
Targeted Allele Detail
Summary
Symbol: Smad3tm1Cxd
Name: SMAD family member 3; targeted mutation 1, Chu-Xia Deng
MGI ID: MGI:1857695
Synonyms: Smad3-, Smad3delEx8, Smad3ex8
Gene: Smad3  Location: Chr9:63554049-63665276 bp, - strand  Genetic Position: Chr9, 34.22 cM, cytoband D
Alliance: Smad3tm1Cxd page
Skeletal defects in 7 month old Smad3tm1Cxd/Smad3tm1Cxd mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:53510
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exon 8 of the gene, which truncated the protein 89 amino acids from the C-terminal end. (J:53510)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 30 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Smad3tm1Cxd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Smad3 Mutation:  18 strains or lines available
References
Original:  J:53510 Yang X, et al., Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J. 1999 Mar 1;18(5):1280-91
All:  144 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
05/14/2024
MGI 6.23
The Jackson Laboratory