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Targeted Allele Detail
Symbol: Errfi1tm1Gvw
Name: ERBB receptor feedback inhibitor 1; targeted mutation 1, George F Vande Woude
MGI ID: MGI:3603195
Synonyms: Mig-6-
Gene: Errfi1  Location: Chr4:150938376-150953349 bp, + strand  Genetic Position: Chr4, 81.5 cM, cytoband E1
Alliance: Errfi1tm1Gvw page
Errfi1tm1Gvw/Errfi1tm1Gvw mouse joints display pathological features of osteoarthritis

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:100927
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe entire coding region (exons 2-4) were replaced with a pgk-neomycin resistance gene. Absence of transcript was demonstrated in Northern blot of mutant liver and thymus. (J:100927)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Errfi1tm1Gvw
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Errfi1 Mutation:  18 strains or lines available
Original:  J:100927 Zhang YW, et al., Targeted disruption of Mig-6 in the mouse genome leads to early onset degenerative joint disease. Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11740-5
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory