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Targeted Allele Detail
Symbol: Fmodtm1Aol
Name: fibromodulin; targeted mutation 1, Ake Oldberg
MGI ID: MGI:2154550
Synonyms: Fmod-
Gene: Fmod  Location: Chr1:133964992-133976015 bp, + strand  Genetic Position: Chr1, 58.09 cM
Alliance: Fmodtm1Aol page
Abnormal tendon collagen fiber bundles in Fmodtm1Aol/Fmod+ and Fmodtm1Aol/Fmodtm1Aol tails

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:54069
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 2, at a position corresponding to amino acid 8 (tryptophan) in the mature protein. (J:54069)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fmod Mutation:  22 strains or lines available
Phenotypic Similarity to Human Syndrome: Temporomandibular Joint Osteoarthritis J:112779, J:117908, J:226593 in mice homozygous or hemizygous for Bgntm1Mfy and homozygous for Fmodtm1Aol.
Original:  J:54069 Svensson L, et al., Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendon. J Biol Chem. 1999 Apr 2;274(14):9636-47
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory