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Targeted Allele Detail
Symbol: Tgfbr1tm1.1Karl
Name: transforming growth factor, beta receptor I; targeted mutation 1.1, Stefan Karlsson
MGI ID: MGI:2680164
Synonyms: Alk5Flox, Alk5loxP, Tgfbr1f
Gene: Tgfbr1  Location: Chr4:47353222-47414926 bp, + strand  Genetic Position: Chr4, 26.02 cM
Alliance: Tgfbr1tm1.1Karl page
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl Ptentm1Hwu/Ptentm1Hwu Tg(KRT14-cre/ERT)20Efu/0 mice develop anal squamous cell carcinoma

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:86262
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 3 was left flanked by single loxP sites after the removal of an upstream floxed neo cassette by the transient expression of cre recombinase in ES cells. (J:86262)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 102 assay results
5 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 11 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Tgfbr1tm1.1Karl
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfbr1 Mutation:  36 strains or lines available
ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+) or GS (129S6/SvEvTac).
Original:  J:68770 Larsson J, et al., Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J. 2001 Apr 2;20(7):1663-73
All:  101 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.23
The Jackson Laboratory