Tfrc^tm3.1Nca
Targeted Allele Detail

Summary

• Symbol: Tfrc^tm3.1Nca
• Name: transferrin receptor; targeted mutation 3.1, Nancy C Andrews
• MGI ID: MGI:5689121
• Synonyms: Tfr1^fl
• Gene: Tfrc Location: Chr16:32427738-32451612 bp, + strand Genetic Position: Chr16, 23.06 cM
• Alliance: Tfrc^tm3.1Nca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224823
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP-flanked neomycin resistance cassette (neo^r) was introduced into intron 2 and a third loxP site into intron 6. The neo^r was deleted by cre recombinase expression, leaving exons 3-6 flanked by loxP sites. (J:224823)

Disease models

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Tfrc Mutation: 61 strains or lines available

References

• Original: J:224823 Chen AC, et al., Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11714-9
• All: 13 reference(s)