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All mouse models of vascular disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | aortic aneurysm |
\Agtr2tm1Tin/Y \Efemp2tm1.1Hiya/\Efemp2tm1.2Hiya \Tg(Tagln-cre)1Her/0 |
involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * SJL | J:213282 | View | |||
| aortic aneurysm |
\Efemp2tm1.1Hiya/\Efemp2tm1.2Hiya \Tg(Tagln-cre)1Her/0 |
involves: 129S6/SvEvTac * C57BL/6 * SJL | J:213282 | View | ||||
| arterial calcification of infancy | \Enpp1asj-2J/\Enpp1asj-2J | BALB/cJ-Enpp1asj-2J/GrsrJ | J:215824 | View | ||||
| arterial calcification of infancy | \Enpp1asj/\Enpp1asj | C57BL/6J-Enpp1asj/GrsrJ | J:201689 | View | ||||
| arteriovenous malformations of the brain | \Engtm2.1Hma/\Engtm2.1Hma | involves: 129P2/OlaHsd | J:196810 | View | ||||
| arteriovenous malformations of the brain |
\Krastm4Tyj/\Kras+ \Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129S4/SvJae * FVB | J:312482 | View | ||||
| arteriovenous malformations of the brain |
\Krastm4Tyj/\Kras+ \Tg(Slco1c1-icre/ERT2)1Mash/0 |
involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB | J:312482 | View | ||||
| cerebral cavernous malformation |
\Krit1tm1Kwhi/\Krit1tm1Kwhi \Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129S6/SvEvTac * C57BL/6NCrl | J:232707, J:250906 | View | ||||
| cerebral cavernous malformation 2 |
\Ccm2tm1.1Etl/\Ccm2tm1Etl \Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129 * C57BL/6 | J:177584 | View | ||||
| cerebral cavernous malformation 2 |
\Ccm2tm1Kwhi/\Ccm2tm1.1Kwhi \Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/? |
involves: C57BL/6 * CBA | J:173947 | View | ||||
| cerebral cavernous malformation 2 |
\Ccm2tm1Mlkn/\Ccm2tm1Mlkn \Tg(Cdh5-cre/ERT2)1Rha/0 |
involves: 129 | J:250906 | View | ||||
| cerebral cavernous malformation 2 |
\Ccm2tm2.1Sbn/\Ccm2tm2.1Sbn \Tg(Mx1-cre)1Cgn/0 |
involves: C57BL/6 * CBA | J:174085 | View | ||||
| cerebral cavernous malformation 3 |
\Pdcd10tm1Kwhi/\Pdcd10tm1.1Kwhi \Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/? |
involves: C57BL/6 * CBA | J:173947 | View | ||||
| cerebral cavernous malformation 3 |
\Pdcd10tm1Wami/\Pdcd10tm1Wami \Tg(GFAP-cre)25Mes/0 |
involves: 129 * C57BL/6 * FVB/N | J:170480 | View | ||||
| essential hypertension | \Nos3tm1Gdk/\Nos3tm1Gdk | involves: 129P2/OlaHsd * C57BL/6 | J:46061 | View | ||||
| essential hypertension | \Nos3tm1Plh/\Nos3tm1Plh | involves: 129S4/SvJae | J:28778 | View | ||||
| essential hypertension | \Nos3tm1Unc/\Nos3tm1Unc | involves: 129P2/OlaHsd | J:103153 | View | ||||
| hereditary hemorrhagic telangiectasia | \Acvrl1tm1Enl/\Acvrl1+ | involves: C57BL/6 | J:82115 | View | ||||
| hereditary hemorrhagic telangiectasia |
\Acvrl1tm2.1Spo/\Acvrl1tm2.1Spo \Gt(ROSA)26Sortm1(cre/ERT)Nat/\Gt(ROSA)26Sor+ |
involves: 129 * 129S1/Sv * 129X1/SvJ | J:154620 | View | ||||
| hereditary hemorrhagic telangiectasia |
\Acvrl1tm2.1Spo/\Acvrl1tm2.1Spo \Tg(Acvrl1-cre)L1Spo/0 |
involves: 129 * FVB | J:154620 | View | ||||
| hereditary hemorrhagic telangiectasia |
\Acvrl1tm2.1Spo/\Acvrl1tm2.1Spo \Tg(Tal1-cre/ERT)1Jrg/0 |
involves: 129 * C57BL/6 | J:227170 | View | ||||
| hereditary hemorrhagic telangiectasia |
\Acvrl1tm2Spo/\Acvrl1tm2Spo \Tg(Acvrl1-cre)L1Spo/0 |
involves: 129 * 129S4/SvJae * C57BL/6 * FVB/N | J:130020 | View | ||||
| hereditary hemorrhagic telangiectasia | \Engtm1Dyl/\Engtm1Dyl | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:55403 | View | ||||
| hereditary hemorrhagic telangiectasia | \Engtm1Hma/\Eng+ | 129P2/OlaHsd-Engtm1Hma | J:73415 | View | ||||
| hereditary hemorrhagic telangiectasia | \Engtm1Mle/\Eng+ | 129P2/OlaHsd-Engtm1Mle | J:58502 | View | ||||
| hereditary hemorrhagic telangiectasia | \Engtm1Mle/\Eng+ | involves: 129P2/OlaHsd * C57BL/6 | J:58502 | View | ||||
| hereditary hemorrhagic telangiectasia |
\Engtm2.1Hma/\Engtm2.1Hma \Gt(ROSA)26Sortm1(cre/ERT)Nat/\Gt(ROSA)26Sor+ |
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ | J:212952, J:227170 | View | ||||
| hereditary hemorrhagic telangiectasia |
\Engtm2.1Hma/\Engtm2.1Hma \Tg(Tagln-cre)1Her/0 |
involves: 129P2/OlaHsd * C57BL/6 * SJL | J:212952 | View | ||||
| Marfan syndrome | \Fbn1tm1Hcd/\Fbn1+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:91349, J:94428 | View | ||||
| Marfan syndrome | \Fbn1tm1Lper/\Fbn1+ | involves: 129/Sv * C57BL/6 * CD-1 | J:167276 | View | ||||
| Marfan syndrome | \Fbn1tm1Lper/\Fbn1+ | involves: 129/Sv * CD-1 | J:167276 | View | ||||
| Marfan syndrome | \Fbn1tm1Rmz/\Fbn1tm1Rmz | involves: 129S4/SvJae * C57BL/6J | J:43199 | View | ||||
| Marfan syndrome | \Fbn1tm2Rmz/\Fbn1tm2Rmz | involves: 129S1/Sv * 129X1/SvJ | J:54081 | View | ||||
| Marfan syndrome | \Fbn1tm3Rmz/\Fbn1tm3Rmz | Not Specified | J:110586 | View | ||||
| Marfan syndrome | \Fbn1Tsk/\Fbn1+ | B6.Cg-Fbn1Tsk | J:30961 | View | ||||
| Marfan syndrome | \Fbn1Tsk/\Fbn1+ | B10.D2/(58N)Sn | J:21512 | View | ||||
| persistent fetal circulation syndrome | \Foxf1em1Vvk/\Foxf1+ | involves: C57BL/6 * DBA/2 | J:296328 | View | ||||
| supravalvular aortic stenosis | \Elntm1Dyl/\Eln+ | B6.129-Elntm1Dyl | J:86535 | View | ||||
| supravalvular aortic stenosis | \Elntm1Dyl/\Eln+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:51109 | View | ||||
| von Hippel-Lindau disease |
\Hif1atm3Rsjo/\Hif1atm3Rsjo \Hprt1tm1(Pck1-cre)Vhh/Y \Vhltm1Jae/\Vhltm1Jae |
involves: 129 * BALB/c * C57BL/6 | J:97652, J:106705 | View | ||||
| von Hippel-Lindau disease |
\Hif1atm3Rsjo/\Hif1atm3Rsjo \Vhltm1Jae/\Vhltm1Jae \Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+ |
involves: 129 * BALB/c * C57BL/6 * DBA | J:97652 | View | ||||
| von Hippel-Lindau disease |
\Hprt1tm1(Pck1-cre)Vhh/Y \Vhltm1Jae/\Vhltm1Jae |
involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6 | J:97652, J:106705 | View | ||||
| von Hippel-Lindau disease |
\Ptentm1Hwu/\Ptentm1Hwu \Vhltm1Jae/\Vhltm1Jae \Tg(Cdh16-cre)91Igr/0 |
involves: 129S4/SvJae * BALB/c * C57BL/6J * ICR | J:137073 | View | ||||
| von Hippel-Lindau disease |
\Ptentm1Hwu/\Ptentm1Hwu \Vhltm1Jae/\Vhltm1Jae \Tg(Cdh16-cre)91Igr/0 |
involves: 129S4/SvJae * ICR | J:137442 | View | ||||
| von Hippel-Lindau disease | \Vhltm1.1Jae/\Vhl+ | involves: 129S4/SvJae * BALB/c | J:67505 | View | ||||
| von Hippel-Lindau disease | \Vhltm1.1Lss/\Vhl+ | involves: A/J | J:85513 | View | ||||
| von Hippel-Lindau disease | \Vhltm1.1Lss/\Vhl+ | involves: BALB/c | J:85513 | View | ||||
| von Hippel-Lindau disease | \Vhltm1.1Wkr/\Vhl+ | involves: 129S4/SvJae * C57BL/6 | J:157369 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Jae/\Vhltm1Jae \Speer6-ps1Tg(Alb-cre)21Mgn/\Speer6-ps1+ |
involves: 129S4/SvJae * BALB/c * C57BL/6 * DBA | J:67505, J:97652 | View | ||||
| von Hippel-Lindau disease | \Vhltm1Lss/\Vhltm1.1Lss | involves: 129X1/SvJ * C57BL/6 | J:85513 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Lss/\Vhltm1.1Lss \Tg(ACTB-cre)1Tes/0 |
involves: 129X1/SvJ * C3H * C57BL/6 | J:85513 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Lss/\Vhltm1Lss \Tg(Gcg-cre)1Slib/0 |
either: (involves: 129X1/SvJ * A/J) or (involves: 129X1/SvJ * C57BL/6) | J:148174 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Lss/\Vhltm1Lss \Tg(Ins2-cre)25Mgn/0 |
either: (involves: 129X1/SvJ * C57BL/6 * DBA) or (involves: 129X1/SvJ * A/J * C57BL/6 * DBA) | J:148174 | View | ||||
| von Hippel-Lindau disease |
\Vhltm1Lss/\Vhltm1Lss \Tg(Pdx1-cre)89.1Dam/0 |
involves: 129X1/SvJ * C57BL/6 * CBA | J:148174 | View | ||||
| von Hippel-Lindau disease | \Vhltm1Wml/\Vhltm1Wml | involves: 129S4/SvJae * C57BL/6 | J:42846, J:88492 | View | ||||
| | aortic aneurysm | \Atp7aMo-blo/\Atp7a+ | Not Specified | J:5516 | View | |||
| aortic aneurysm | \Atp7aMo-blo/Y | Not Specified | J:5516, J:15796 | View | ||||
| aortic aneurysm | \Klf15tm1Jain/\Klf15tm1Jain | B6.129X1-Klf15tm1Jain | J:167880 | View | ||||
| aortic dissection |
\Best3tm1.1Zhoj/\Best3tm1.1Zhoj \Tg(Tagln-cre)1Her/0 |
involves: C57BL/6 * SJL | J:338981 | View | ||||
| aortic valve disease | \Adamts19tm4a(EUCOMM)Wtsi/\Adamts19tm4a(EUCOMM)Wtsi | C57BL/6N-Adamts19tm4a(EUCOMM)Wtsi | J:287334 | View | ||||
| aortic valve disease | \Adamts19tm4b(EUCOMM)Wtsi/\Adamts19tm4b(EUCOMM)Wtsi | B6N(Cg)-Adamts19tm4b(EUCOMM)Wtsi | J:287334 | View | ||||
| aortic valve disease | \Egfrwa2/\Egfrwa2 | involves: C57BL/6 | J:241813 | View | ||||
| aortic valve disease | \Egfrwa2/\Egfrwa2 | STOCK Egfrwa2 | J:60750 | View | ||||
| aortic valve disease | \Elntm1Dyl/\Eln+ | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:184494 | View | ||||
| aortic valve disease | \Hey2tm1Kkb/\Hey2tm1Kkb | involves: 129S7/SvEvBrd * C57BL/6 | J:216895 | View | ||||
| aortic valve disease | \Nos3tm1Unc/\Nos3tm1Unc | B6.129P2-Nos3tm1Unc/J | J:103340 | View | ||||
| aortic valve disease | \Rbpjtm1Kyo/\Rbpj+ | involves: 129S2/SvPas * CD-1 | J:187551 | View | ||||
| aortic valve stenosis | \Tnftm2Gkl/\Tnf+ | involves: 129S/SvEv * C57BL/6J | J:264147 | View | ||||
| arteriovenous malformations of the brain | \Acvrl1tm2.1Spo/\Acvrl1tm2.1Spo | involves: 129 | J:196810 | View | ||||
| arteriovenous malformations of the brain |
\Tg(Tek-tTA)1Rwng/0 \Tg(tetO-Notch4*)1Rwng/0 |
involves: FVB/N | J:139943 | View | ||||
| Caroli syndrome | \Pkhd1cyli/\Pkhd1cyli | D2.Cg-(D4Mit42-D4Smh6b) Pkhd1cyli/EiJ | J:343537 | View | ||||
| coronary artery disease | \Kcnj8tm1Sse/\Kcnj8tm1Sse | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:76195 | View | ||||
| diabetic retinopathy |
\Insrtm1Khn/\Insrtm1Khn \Tg(Pdgfrb-cre)#Rha/0 |
involves: 129S4/SvJae * C57BL/6J | J:327000 | View | ||||
| essential hypertension | \Elntm1Dyl/\Eln+ | B6.129-Elntm1Dyl | J:86535 | View | ||||
| essential hypertension | \Gata5tm1.2Nemr/\Gata5tm1.2Nemr | Not Specified | J:227997 | View | ||||
| exudative vitreoretinopathy |
\Capslem1Xjz/\Capslem1Xjz \Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: C57BL/6 * C57BL/6J * CBA | J:365043 | View | ||||
| exudative vitreoretinopathy |
\Cdh5tm1Dvst/\Cdh5tm1Dvst \Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: C57BL/6 * CBA | J:328283 | View | ||||
| exudative vitreoretinopathy |
\Ctnnb1em1V/\Ctnnb1em1V \Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: C57BL/6 * C57BL/6J * CBA | J:328283 | View | ||||
| exudative vitreoretinopathy | \Fzd4tm1Nat/\Fzd4tm1Nat | involves: 129S1/Sv * 129X1/SvJ | J:158585 | View | ||||
| exudative vitreoretinopathy | \Fzd4tm1Nat/\Fzd4tm1Nat | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:328283 | View | ||||
| exudative vitreoretinopathy | \Lrp5em1Xjz/\Lrp5em1Xjz | C57BL/6J-Lrp5em1Xjz | J:328283 | View | ||||
| exudative vitreoretinopathy | \Lrp5r18/\Lrp5r18 | C57BL/6J-Lrp5r18 | J:135279 | View | ||||
| exudative vitreoretinopathy | \Lrp5tm1Dgen/\Lrp5tm1Dgen | B6.129P2-Lrp5tm1Dgen/J | J:235600 | View | ||||
| exudative vitreoretinopathy | \Lrp5tm1Dgen/\Lrp5tm1Dgen | involves: 129P2/OlaHsd * C57BL/6 | J:328283 | View | ||||
| exudative vitreoretinopathy | \Ndptm1Wbrg/Y | involves: 129P2/OlaHsd * C57BL/6 | J:158585 | View | ||||
| exudative vitreoretinopathy | \Tspan12tm1Wye/\Tspan12tm1Wye | either: B6.129S5-Tspan12tm1Wye or FVB.129S5-Tspan12tm1Wye | J:158585 | View | ||||
| hypertension | \Nppatm1Unc/\Nppa+ | involves: 129P2/OlaHsd * C57BL/6J | J:76312 | View | ||||
| hypertension | \Nppatm1Unc/\Nppatm1Unc | involves: 129P2/OlaHsd * C57BL/6 | J:76312 | View | ||||
| Marfan syndrome | \Mus81tm1Esse/\Mus81tm1Esse | involves: 129P2/OlaHsd * C57BL/6 | J:133703 | View | ||||
| persistent fetal circulation syndrome | \Nos3tm1Unc/\Nos3tm1Unc | B6.129P2-Nos3tm1Unc/J | J:98913 | View | ||||
| persistent fetal circulation syndrome |
\Ptentm1Hwu/\Ptentm1Hwu \Twist2tm1.1(cre)Dor/\Twist2+ |
B6.129-Twist2tm1.1(cre)Dor Ptentm1Hwu | J:192736 | View | ||||
| pre-eclampsia | \Apelatm1.2Brre/\Apelatm1.2Brre | B6(Cg)-Apelatm1.2Brre | J:244834 | View | ||||
| pre-eclampsia | \Asb4tm1.2Cpat/\Asb4tm1.2Cpat | involves: 129/SvEv | J:238841 | View | ||||
| pre-eclampsia | \Cdkn1ctm1Kat/\Cdkn1c+ | involves: 129P2/OlaHsd | J:102331 | View | ||||
| pre-eclampsia | \Cdkn1ctm1Kat/\Cdkn1ctm1Kat | involves: 129P2/OlaHsd | J:102331 | View | ||||
| pre-eclampsia | \Comttm1Kara/\Comttm1Kara | involves: 129S4/SvJaeSor | J:137276 | View | ||||
| pre-eclampsia | \Ido1tm1.1Mkks/\Ido1tm1.1Mkks | B6.Cg-Ido1tm1.1Mkks | J:229059 | View | ||||
| pre-eclampsia |
\Notch2tm3Grid/\Notch2tm3Grid \Tg(Tpbpa-cre,-EGFP)5Jcc/0 |
involves: 129S1/Sv | J:173527 | View | ||||
| pre-eclampsia | \Ptgs1tm1Fun/\Ptgs1tm1Fun | involves: 129S6/SvEvTac * C57BL/6 | J:97351 | View | ||||
| pulmonary hypertension | \Cavin1tm1Pfp/\Cavin1tm1Pfp | B6.129S6-Cavin1tm1Pfp/J | J:217258 | View | ||||
| retinal vein occlusion | \Nrp1tm1.1Cruh/\Nrp1tm1.1Cruh | involves: C57BL/6 | J:176047 | View | ||||
| severe nonproliferative diabetic retinopathy | \Pdgfrbredeye/\Pdgfrbredeye | C3N.C-Pdgfrbredeye | J:199483 | View | ||||
| | coronary artery disease |
\Apoetm1Unc/\Apoetm1Unc \Scarb1tm1Kri/\Scarb1tm1Kri |
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 | J:201999 | View | |||
| Transgenes and Other Mutations | brain ischemia | \Tg(Notch3*R169C)88Bbb/0 | involves: FVB/N | J:156682 | View | |||
| von Hippel-Lindau disease | \Tg(Ggt1-Hif1a*)43Log/0 | involves: C57BL/6 | J:177381 | View | ||||
| Additional Complex Models | aortic valve disease |
\Apobtm2Sgy/\Apobtm2Sgy \Ldlrtm1Her/\Ldlrtm1Her \Tg(Ins-Igf2)1Fbos/? |
involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J * SJL | J:227165 | View | |||
| coronary artery disease | \Abcc9tm1Cfb/\Abcc9tm1Cfb | Not Specified | J:78066 | View | ||||
| diabetic angiopathy |
\Ins2Akita/\Ins2Akita \Ldlrtm1Her/\Ldlrtm1Her |
B6.Cg-Ins2Akita Ldlrtm1Her | J:174983 | View | ||||
| exudative vitreoretinopathy |
\Ctnna1em1Xjz/\Ctnna1tm1Efu \Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/\Gt(ROSA)26Sor+ \Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6J * C57BL/6NCrl * CBA | J:328283 | View | ||||
| exudative vitreoretinopathy |
\Ctnna1tm1Efu/\Ctnna1tm1Efu \Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/\Gt(ROSA)26Sor+ \Tg(Pdgfb-icre/ERT2,-EGFP)1Frut/0 |
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * C57BL/6NCrl * CBA | J:328283 | View | ||||
| pre-eclampsia |
\Adatm1Mw/\Adatm1Mw \Tg(Afp-ADA)#Xiay/0 |
involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J | J:234143 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | cerebral cavernous malformation 2 |
\Ccm2tm1Etl/\Ccm2tm1Etl \Tg(Nes-cre)1Kln/? |
B6.Cg-Ccm2tm1Etl Tg(Nes-cre)1Kln | J:146210 | View | |||
| cerebral cavernous malformation 2 |
\Ccm2tm2.1Sbn/\Ccm2tm2.1Sbn \Tg(Tek-cre)1Ywa/0 |
involves: C57BL/6 * SJL | J:174085 | View | ||||
| coronary artery disease |
\Apoetm1Unc/\Apoetm1Unc \Svep1em1Nost/\Svep1em1Nost |
involves: 129P2/OlaHsd * C57BL/6 | J:304349 | View | ||||
| essential hypertension | \Tnfrsf1btm1Imx/\Tnfrsf1btm1Imx | involves: 129S7/SvEvBrd * C57BL/6 | J:45147 | View | ||||
| Marfan syndrome | \Fbn1tm3.2Lysa/\Fbn1+ | Not Specified | J:181493 | View | ||||
| Marfan syndrome | \Fbn1tm3.2Lysa/\Fbn1tm3.2Lysa | Not Specified | J:181493 | View | ||||
| Moyamoya disease | \Rnf213tm1.1Mfuji/\Rnf213tm1.1Mfuji | involves: C57BL/6 | J:229422 | View | ||||