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Phenotypes Associated with This Genotype
Genotype
MGI:7327617
Allelic
Composition
Insrtm1Khn/Insrtm1Khn
Tg(Pdgfrb-cre)#Rha/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insrtm1Khn mutation (1 available); any Insr mutation (94 available)
Tg(Pdgfrb-cre)#Rha mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• mice show increased vascularity in the regions adjacent to retinal veins
• the number of sprouting tip cells is increased indicating increased angiogenic sporouting in superficial and deep layers
• however, pericyte coverage of capillaries is unaltered in perivenous and periartieral plexi and no differences in vascular regression or endothelial proliferation is seen
• mice show increased retinal vein diameter at P5 and P10
• mice show impaired venous pattering during developmental retinal angiogenesis with increased branching complexity in the peripheral half of the plexus at P5

cardiovascular system
• mice show increased vascularity in the regions adjacent to retinal veins
• the number of sprouting tip cells is increased indicating increased angiogenic sporouting in superficial and deep layers
• however, pericyte coverage of capillaries is unaltered in perivenous and periartieral plexi and no differences in vascular regression or endothelial proliferation is seen
• mice show increased retinal vein diameter at P5 and P10
• mice show impaired venous pattering during developmental retinal angiogenesis with increased branching complexity in the peripheral half of the plexus at P5
• mice exhibit abnormal retinal venous plexus development in early postnatal life, with increased branching complexity in the peripheral half of the plexus, increased venous plexus vascular density but not arterial plexus density, and increased vascular area of the deep vascular plexus indicating venous plexus hypervascularity
• perivenous hypervascularity diminishes with time, although it is still evident at P10

homeostasis/metabolism
• fasting serum insulin is increased in 8-week-old mice
• however, fasting serum glucose is normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
diabetic retinopathy DOID:8947 J:327000


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory