About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2676253
Allelic
Composition
Ndptm1Wbrg/Y
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndptm1Wbrg mutation (0 available); any Ndp mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
vision/eye
• hyperpigmentation of the retinal pigment epithelium is evident within severely affectes areas
• at 4 and 26 weeks, a general disorganization of the ganglion cell layer is observed, with some nuclei migrating into the inner plexiform layer
• at 4 and 26 weeks, occasional changes in the inner nuclear layers are observed
• nuclei from the inner nuclear layer are occasionally displaced into the photoreceptor layer
• even when inner nuclear and photoreceptor layers are only mildly affected, the changes within the vitreous body and the ganglion cell layer are prominent
• at 4 and 26 weeks, occasional changes in the outer nuclear layers are observed
• nuclei from the outer nuclear layer are occasionally displaced into the outer plexiform and the inner nuclear layer
• the outer plexiform layer disappears in severely affected areas
• relocation of nuclei from the inner nuclear layers into the photoreceptor layer leads to the disappearance of photoreceptors
• the outer segments of the photoreceptor cells disappear within severely affected areas
• at 3 weeks, 3 of 6 male hemizygotes exhibit conspicuous precipitate-like retrolental structures in the vitreous body; the variation in number and size of precipitates is age-independent
• by 10-20 weeks, all male hemizygotes show pathological signs with a variable age of onset
• in addition to the precipitates, depigmented bundles or stripes are noted in some eyes and interpreted as retinal folding or detachment
• at 4 and 26 weeks, fibrous masses (retrolental patterns) are observed within the vitreous bodies of all eyes examined

pigmentation
• hyperpigmentation of the retinal pigment epithelium is evident within severely affectes areas

nervous system
• relocation of nuclei from the inner nuclear layers into the photoreceptor layer leads to the disappearance of photoreceptors
• the outer segments of the photoreceptor cells disappear within severely affected areas


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory