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Phenotypes Associated with This Genotype
Genotype
MGI:5288006
Allelic
Composition
Notch2tm3Grid/Notch2tm3Grid
Tg(Tpbpa-cre,-EGFP)5Jcc/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Notch2tm3Grid mutation (2 available); any Notch2 mutation (97 available)
Tg(Tpbpa-cre,-EGFP)5Jcc mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• trophoblast giant cells and glycogen trophoblast cells fail to invade maternal spiral arterioles at E12.5 indicating a failure of endovascular invasion
• trophoblast-lined canals in the placenta that transport maternal blood to the labyrinth are reduced in size by 30-40%
• placentas fail to remodel maternal blood vessels adequately resulting in reduced placental perfusion by about 23% in mutants

embryo
• trophoblast giant cells and glycogen trophoblast cells fail to invade maternal spiral arterioles at E12.5 indicating a failure of endovascular invasion
• trophoblast-lined canals in the placenta that transport maternal blood to the labyrinth are reduced in size by 30-40%
• placentas fail to remodel maternal blood vessels adequately resulting in reduced placental perfusion by about 23% in mutants

endocrine/exocrine glands
• females exhibit severe ovarian defects

reproductive system
• females exhibit severe ovarian defects
• homozygous mothers mated with homozygous males exhibit a loss of embryos as early as E9.5, with 54% resorption between E11.5 and E14.5
• homozygous mothers mated with heterozygous males and heterozygous mothers mated with homozygous males exhibit a similar loss of both heterozygous and homozygous embryos, indicating that lethality is not due to maternal factors and is correlated with the presence of homozygous embryos rather than the genotype of individual embryos
• homozygous mothers have fewer implantation sites than controls

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pre-eclampsia DOID:10591 OMIM:189800
OMIM:609402
OMIM:609403
OMIM:609404
OMIM:614592
J:173527


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory