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Tg(Cdh5-cre/ERT2)1Rha
Transgene Detail
Summary
Symbol: Tg(Cdh5-cre/ERT2)1Rha
Name: transgene insertion 1, Ralf H Adams
MGI ID: MGI:3848982
Synonyms: Cdh5-CreER, Cdh5(PAC)-CreERT2, Tg:VE-cadherin-(PAC)CreERT2, VE-cad::CreER, VeCadCreERT, VE-Cadherin-Cre-ERT, VE-Cadherin(PAC)-CreERT2
Transgene: Tg(Cdh5-cre/ERT2)1Rha  Location: unknown  
Alliance: Tg(Cdh5-cre/ERT2)1Rha page
Morphometric analysis of aortic root lesions in tamoxifen-treated, high-fat diet fed Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw Nck2tm3Paw/Nck2tm3Paw mice.

Show the 4 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Mutation detailsThe tamoxifen-inducible cre/ERT2 sequence was inserted into a PAC (P1 artificial chromosome) containing the VE-cadherin (Cdh5) gene to generate the transgene construct. (J:148902)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdh5 (species not specified)
Summary of all recombinase alleles driven by Cdh5.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Tg(Cdh5-cre/ERT2)1Rha
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
References
Original:  J:148902 Sorensen I, et al., DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 2009 May 28;113(22):5680-8
All:  454 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory