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Ptgs1tm1Fun
Targeted Allele Detail
Summary
Symbol: Ptgs1tm1Fun
Name: prostaglandin-endoperoxide synthase 1; targeted mutation 1, Colin D Funk
MGI ID: MGI:3576237
Synonyms: COX-1 KD, PGHS1Neo
Gene: Ptgs1  Location: Chr2:36120438-36142284 bp, + strand  Genetic Position: Chr2, 24.19 cM
Alliance: Ptgs1tm1Fun page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:97351
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsA floxed PGK-neo was inserted into intron 10 to create this hypomorphic allele. Western blot showed that protein was dramatically reduced in mutant macrophages to approximately 10% of wild-type levels. (J:97351)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ptgs1 Mutation:  44 strains or lines available
References
Original:  J:97351 Yu Y, et al., Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. J Clin Invest. 2005 Apr 1;115(4):986-995
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory