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Targeted Allele Detail
Symbol: Apelatm1.2Brre
Name: apelin receptor early endogenous ligand; targeted mutation 1.2, Bruno Reversade
MGI ID: MGI:6118179
Synonyms: Eladelta
Gene: Apela  Location: Chr8:65481069-65489970 bp, - strand  Genetic Position: Chr8, 32.52 cM
Alliance: Apelatm1.2Brre page
Germline Transmission:  Earliest citation of germline transmission: J:244834
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted into intron 2 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination. Exon 3 was deleted through subsequent cre-mediated recombination. Exon 3 codes for the mature peptide, so this creates a null allele. (J:244834)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apela Mutation:  18 strains or lines available
Original:  J:244834 Ho L, et al., ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice. Science. 2017 Aug 18;357(6352):707-713
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory