Phenotypes Associated with This Genotype

Genotype
MGI:5775189

• Allelic Composition: Eng^tm2.1Hma/Eng^tm2.1Hma; Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased locomotor activity ( J:227170 )

• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes slow movement

cardiovascular system

arteriovenous malformation ( J:212952 , J:227170 )

• adults injected with tamoxifen for 3 days develop arteriovenous malformations in AAV-VEGF-induced brain angiogenic foci 8 weeks after induction, with lesions consisting of enlarged vessels (J:212952)

• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)

• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show the presence of arteriovenous (AV) shunts (J:227170)

hemorrhage ( J:212952 )

• macrophages and microhemorrhage are seen around dysplastic vessels of AAV-VEGF injected, tamoxifen treated mice in the brain

abnormal vascular wound healing ( J:212952 , J:227170 )

• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)

• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show dilated and torturous vessels and the presence of arteriovenous (AV) shunts (J:227170)

• however, blood vessels away from the wound have normal morphology (J:227170)

digestive/alimentary system

diarrhea ( J:227170 )

• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes diarrhea

homeostasis/metabolism

abnormal vascular wound healing ( J:212952 , J:227170 )

• tamoxifen treated adults develop arteriovenous malformations around the ear-tag wound (J:212952)

• areas of wounds in mid-dorsum and ear of tamoxifen-injected mice show dilated and torturous vessels and the presence of arteriovenous (AV) shunts (J:227170)

• however, blood vessels away from the wound have normal morphology (J:227170)

dehydration ( J:227170 )

• mice display signs of illness in 3-4 days after the first tamoxifen injection which includes dehydration

mortality/aging

moribund ( J:227170 )

• mice die around day 4-10 after the first tamoxifen treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary hemorrhagic telangiectasia		DOID:1270	OMIM:187300 OMIM:600376 OMIM:601101 OMIM:615506	J:212952 , J:227170