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Phenotypes Associated with This Genotype
Genotype
MGI:2176568
Allelic
Composition
Egfrwa2/Egfrwa2
Genetic
Background
STOCK Egfrwa2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egfrwa2 mutation (3 available); any Egfr mutation (86 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• aortic valve size ranges from unaffected to mildly or markedly thickened
• about 80% exhibit semilunar valve enlargement
• valve abnormalities persist into adulthood causing moderate to severe regurgitation
• higher peak left ventricular systolic pressure and a trend towards increased +dP/dT

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
aortic valve disease DOID:62 J:60750


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory