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Targeted Allele Detail
Symbol: Comttm1Kara
Name: catechol-O-methyltransferase; targeted mutation 1, Maria Karayiorgou
MGI ID: MGI:2178542
Synonyms: COMT-, COMT-ko
Gene: Comt  Location: Chr16:18225636-18245602 bp, - strand  Genetic Position: Chr16, 11.4 cM
Alliance: Comttm1Kara page
Germline Transmission:  Earliest citation of germline transmission: J:49475
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exons 2-4. Northern blot analysis on RNA derived from brain and liver of homozygous mice demonstrated that no detectable transcript was produced from this allele. Activity assays confirmed that no functional protein was expressed in homozygotes. (J:49475)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Comt Mutation:  23 strains or lines available
Original:  J:49475 Gogos JA, et al., Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9991-6
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory