Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comttm1Kara mutation
(0 available);
any
Comt mutation
(23 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comttm1Kara mutation
(0 available);
any
Comt mutation
(23 available)
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behavior/neurological
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• displayed by females in light/dark box tests
• anxiety indicators in males are normal
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cardiovascular system
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• arteries in the decidua of mutant pregnant females contain hyaline-like deposits with foam cells in the wall and thrombosis in the lumen
• these vascular lesions have non-specific IgM deposition in the vessel walls
• vascular defects are not observed in any other organ of pregnant mutant females
• level of von Willebrand factor is diminished in the thrombotic vascular lesions, suggesting endothelial damage
• administration of 2-ME diminishes the vascular abnormalities
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• mutant females exhibit a fluctuation of blood pressure on day 10 of pregnancy that increases significantly compared to wild-type pregnant females or non-pregnant mutant females, indicating gestational hypertension
• blood pressure returns to normal levels within 10 days after delivery
• administration of 2-ME prevents the increase in blood pressure
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embryo
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• placentae/decidua on day 17 of pregnancy weigh less than those of wild-type mice
• administration of 2-ME restores weight of placentae/decidua to normal levels
• abundant eosin-positive deposition is seen in the placentae/decidua of mutant females
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• administration of 2-ME diminishes the vascular abnormalities
• arteries in the decidua of mutant pregnant females contain hyaline-like deposits with foam cells in the wall and thrombosis in the lumen
• these vascular lesions have non-specific IgM deposition in the vessel walls
• vascular defects are not observed in any other organ of pregnant mutant females
• level of von Willebrand factor is diminished in the thrombotic vascular lesions, suggesting endothelial damage
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• arteriopathy in mutants resembles decidual vascular lesions (acute atherosis) in women with pre-eclampsia
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• numbers of decidual NK cells are higher in pregnant mutants than pregnant wild-type females
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• Nos3 expression in the spongiotrophoblast layer of the placenta is decreased in pregnant mutants compared to pregnant controls
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hematopoietic system
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• numbers of decidual NK cells are higher in pregnant mutants than pregnant wild-type females
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homeostasis/metabolism
immune system
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• numbers of decidual NK cells are higher in pregnant mutants than pregnant wild-type females
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• levels of decidual IFN-gamma are higher in pregnant mutants than pregnant wild-type females
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renal/urinary system
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• urinary albumin excretion is higher on day 17 of pregnancy in mutant females than wild-type females
• administration of 2-ME prevents the proteinuria
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• mutant females exhibit kidney glomerular endothelial cell detachment, swelling and vacuolization (endotheliosis) on day 17 of pregnancy
• pregnant females treated with 2-ME do not exhibit glomerular lesions
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reproductive system
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• arteriopathy in mutants resembles decidual vascular lesions (acute atherosis) in women with pre-eclampsia
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• numbers of decidual NK cells are higher in pregnant mutants than pregnant wild-type females
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• females deliver preterm: 19 days after confirmation of a vaginal plug compared to 20.4 days in wild-type mice
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• pregnant mutant females show a higher fetal wastage at E17 compared to wild-type
• administration of 2-ME to females decreases fetal wastage, however administration of oestradiol or 2-hydroxyoestradiol does not
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• females have a higher total number of embryos that wild-type
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endocrine/exocrine glands
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• numbers of decidual NK cells are higher in pregnant mutants than pregnant wild-type females
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Allelic Composition |
Comttm1Kara/Comt+
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Genetic Background |
involves: 129S4/SvJaeSor |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Comttm1Kara mutation
(0 available);
any
Comt mutation
(23 available)
|
|
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behavior/neurological
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• heterozygous males show increased aggression toward other males as compared to either homozygous or wild-type males
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