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Transgenic Allele Detail
Symbol: Speer6-ps1Tg(Alb-cre)21Mgn
Name: spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
MGI ID: MGI:2176228
Synonyms: Albcre, Alb-cre, AlbCre, Alb-Cre, Albcre2, albumin-cre, crAlb, CreALB, Tg(Alb-cre)21Mg
Gene: Speer6-ps1  Location: Chr13:3236206-3239317 bp, + strand  Genetic Position: Chr13, 1.78 cM
Alliance: Speer6-ps1Tg(Alb-cre)21Mgn page
Strain of Origin:  (C57BL/6 x DBA)F2
Transgene Type:    Transgenic (Recombinase)
Mutations:    Insertion, Intragenic deletion
Speer6-ps1Tg(Alb-cre)21Mgn expression driven by 1 gene
Mutation detailsThe transgene contains a 2.34 kb mouse albumin enhancer/promoter (M. Magnuson verified mouse promoter, personal communication), a nuclear localization sequence-modified Cre recombinase gene and a 2.1 kb fragment from the human growth hormone gene. The promoter is active in hepatocyte cells of the liver. 7 copies of the transgene are estimated to be present. Line 21 inserted into the gene at 3172116-3172120 (Build GRCm38/mm10) resulting in a 4 bp deletion. Founder line x has a copy number of approximately 10. (J:51826)
 Tissue activity of this recombinase allele
Driver: Alb (mouse)
Summary of all recombinase alleles driven by Alb.

View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 156356 assay results
Tumor Data
List all tumor models in MMHCdb carrying Speer6-ps1Tg(Alb-cre)21Mgn
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Speer6-ps1 Mutation:  4 strains or lines available
Original:  J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
All:  1347 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory