Speer6-ps1^{Tg(Alb-cre)21Mgn}
Transgenic Allele Detail

Summary

• Symbol: Speer6-ps1^{Tg(Alb-cre)21Mgn}
• Name: spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
• MGI ID: MGI:2176228
• Synonyms: Alb^cre, Alb-cre, AlbCre, Alb-Cre, Alb^cre2, albumin-cre, cr^Alb, Cre^ALB, Tg(Alb-cre)21Mg
• Gene: Speer6-ps1 Location: Chr13:3236206-3239317 bp, + strand Genetic Position: Chr13, 1.78 cM
• Alliance: Speer6-ps1^{Tg(Alb-cre)21Mgn} page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F2

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Speer6-ps1^{Tg(Alb-cre)21Mgn} expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Alb (MGI:87991)

• Mutation details: The transgene contains a 2.34 kb mouse albumin enhancer/promoter (M. Magnuson verified mouse promoter, personal communication), a nuclear localization sequence-modified Cre recombinase gene and a 2.1 kb fragment from the human growth hormone gene. The promoter is active in hepatocyte cells of the liver. 7 copies of the transgene are estimated to be present. Line 21 inserted into the gene at 3172116-3172120 (Build GRCm38/mm10) resulting in a 4 bp deletion. Founder line x has a copy number of approximately 10. (J:51826)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Alb (mouse) Summary of all recombinase alleles driven by Alb. Comparative matrix view of recombinase activities Alliance mouse Alb gene page

Disease models

Expression

In Mice Carrying this Mutation:

156356 assay results

Tumor Data

List all tumor models in MMHCdb carrying Speer6-ps1^{Tg(Alb-cre)21Mgn}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 6 strains available Cell Lines: 0 lines available
• Carrying any Speer6-ps1 Mutation: 4 strains or lines available

References

• Original: J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
• All: 1347 reference(s)