Tg(Ins-Igf2)1Fbos
Transgene Detail

Summary

• Symbol: Tg(Ins-Igf2)1Fbos
• Name: transgene insertion 1, Fatima Bosch
• MGI ID: MGI:3818739
• Synonyms: RIPI/IGF-II
• Transgene: Tg(Ins-Igf2)1Fbos Location: unknown
• Alliance: Tg(Ins-Igf2)1Fbos page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ins-Igf2)1Fbos expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igf2 (MGI:96434)

• Mutation details: The rat promoter was used to drive islet-specific expression of the mouse gene. Three lines were created (lines 1, 2 and 3) with similar phenotype. Line 1 was chosen as the representative line and has 40 copies of the transgene. (J:141527)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Phenotypic Similarity to Human Syndrome: Calcific Aortic Valve Disease J:227165 in mice homozygous for Apob^tm2Sgy and Ldlr^tm1Her and carrying the Tg(Ins-Igf2)1Fbos transgene.

References

• Original: J:141527 Devedjian JC, et al., Transgenic mice overexpressing insulin-like growth factor-II in beta cells develop type 2 diabetes. J Clin Invest. 2000 Mar;105(6):731-40
• All: 11 reference(s)