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Phenotypes Associated with This Genotype
Genotype
MGI:6118197
Allelic
Composition
Apelatm1.2Brre/Apelatm1.2Brre
Genetic
Background
B6(Cg)-Apelatm1.2Brre
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apelatm1.2Brre mutation (0 available); any Apela mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in 42.6% of E10.5 embryos
• endotheliosis in mothers post parturition
• occluded capillaries in pregnant mothers
• evidence of protein and vesicular deposition on endothelial cells in pregnant mothers
• coagulation of red blood cells in capillary lumens in pregnant mothers
• in 42.6% of E10.5 embryos
• failure of remodeling and angiogenic sprouting of endothelial plexus in many E10.5 embryo placentas
• expansion of endothelial tip versus stalk cells in E9.5 embryo placentas
• absent in many E10.5 embryos
• absent in many E10.5 embryos
• in many E10.5 embryos
• in many E10.5 embryos
• poorly looped, with reduced smooth actin muscle staining in many E10.5 embryos
• in the most severely affected E10.5 embryos
• in pregnant mothers mated to homozygous knockout males
• post parturition

embryo
N
• no obvious phenotype in 48.9% of E10.5 embryos
• in many E10.5 embryos
• in many E10.5 embryos
• delayed development in 8.5% of E10.5 embryos
• of E18.5 embryos recovered from homozygous knockout mothers by caesarean section
• reduced proliferation in many E10.5 embryos
• in many E10.5 embryos
• delayed differentiation according to reduced alkaline phosphatase and syncytin 1 activity in most E10.5 embryos
• hypovascular yolk sac in 8.5% of E10.5 embryos
• avascular yolk sac in 42.6% of E10.5 embryos

renal/urinary system
N
• normal podocytes in pregnant mothers
• endotheliosis in mothers post parturition
• occluded capillaries in pregnant mothers
• evidence of protein and vesicular deposition on endothelial cells in pregnant mothers
• coagulation of red blood cells in capillary lumens in pregnant mothers
• in pregnant mothers at gestational day 15; more severe when mated to homozygous knockout than wildtype males
• evidence of protein deposition on endothelial cells in pregnant mothers

cellular
• in many E10.5 embryos
• decreased weight of E18.5 homozygous knockout embryos recovered by caesarean section
• only one-third the expected number of homozygous knockout embryos seen at weaning age with homozygous knockout mothers crossed with heterozygous fathers
• reduction in the expected number of homozygous knockout embryos seen at E10.5 with homozygous knockout mothers crossed with heterozygous fathers

growth/size/body
• delayed development in 8.5% of E10.5 embryos
• of E18.5 embryos recovered from homozygous knockout mothers by caesarean section

homeostasis/metabolism
• in the most severely affected E10.5 embryos
• in pregnant mothers at gestational day 15; more severe when mated to homozygous knockout than wildtype males

mortality/aging
• only half the expected number of homozygous knockout embryos seen at weaning age with heterozygous mothers crossed with heterozygous fathers
• only one-third the expected number of homozygous knockout embryos seen at weaning age with homozygous knockout mothers crossed with heterozygous fathers

reproductive system
• only one-third the expected number of homozygous knockout embryos seen at weaning age with homozygous knockout mothers crossed with heterozygous father
• reduction in the expected number of homozygous knockout embryos seen at E10.5 with homozygous knockout mothers crossed with heterozygous fathers

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pre-eclampsia DOID:10591 OMIM:189800
OMIM:609402
OMIM:609403
OMIM:609404
OMIM:614592
J:244834


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory