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Cavin1tm1Pfp
Targeted Allele Detail
Summary
Symbol: Cavin1tm1Pfp
Name: caveolae associated 1; targeted mutation 1, Paul F Pilch
MGI ID: MGI:3829005
Synonyms: Cavin-, Cavin1-
Gene: Cavin1  Location: Chr11:100847562-100861443 bp, - strand  Genetic Position: Chr11, 63.95 cM
Alliance: Cavin1tm1Pfp page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:143425
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by western blot analysis on lung and adipocyte extracts. (J:143425)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cavin1 Mutation:  7 strains or lines available
References
Original:  J:143425 Liu L, et al., Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia, and glucose intolerance. Cell Metab. 2008 Oct;8(4):310-7
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory