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Targeted Allele Detail
Symbol: Cdkn1ctm1Kat
Name: cyclin dependent kinase inhibitor 1C; targeted mutation 1, Katsuhiko Takahashi
MGI ID: MGI:1933758
Synonyms: p57-, p57Kip2(-)
Gene: Cdkn1c  Location: Chr7:143012076-143014735 bp, - strand  Genetic Position: Chr7, 88.22 cM
Alliance: Cdkn1ctm1Kat page
Representative testes, seminal vesicles, and uteri from wild-type, Cdkn1ctm1Kat/Cdkn1c+, and Cdkn1ctm1.1(Cdkn1b*)Kei/Cdkn1c+ mice at 7 weeks of age

Show the 5 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:61190
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsReplacement of the entire coding region, including exons 1, 2, 3 and part of exon 4 with a neomycin cassette. (J:61190)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 12 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 25 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cdkn1c Mutation:  19 strains or lines available
Original:  J:61190 Takahashi K, et al., Mice lacking a CDK inhibitor, p57(Kip2), exhibit skeletal abnormalities and growth retardation. J Biochem. 2000 Jan;127(1):73-83
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.13
The Jackson Laboratory