Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm1Kat mutation
(1 available);
any
Cdkn1c mutation
(19 available)
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renal/urinary system
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• by day 17.5 of pregnancy, protein secretion is 5 times greater than in pregnant wild-type mice
• however, after deliver protein secretion is normal
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• glomeruli are enlarged and irregularly shaped with increased subendothelial and mesangial depositions in glomeruli capillaries by day 17.5 of pregnancy unlike in pregnant wild-type mice
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• some pregnant mice exhibit nephrosclerosis unlike pregnant wild-type mice
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• fibroid and hyaline deposits are observed in the proximal and distal tubules of pregnant mice unlike in pregnant wild-type mice
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embryo
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• fewer giant cells invade to maternal vessels at the maternal-fetal interface compared to in wild-type mice
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• the labyrinthine space is narrow unlike in wild-type mice due to increased proliferation of spongio- and labyrinthine trophoblasts
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cardiovascular system
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• systolic blood pressure increases at E9.5 through delivery before retuning to normal unlike pregnant wild-type mice that maintain normal blood pressure throughout pregnancy
• however, after delivery mice exhibit normal blood pressure
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hematopoietic system
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• platelet counts are decreased to 48% of counts in pregnant wild-type by day 17 of pregnancy
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm1Kat mutation
(1 available);
any
Cdkn1c mutation
(19 available)
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mortality/aging
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• slight lethality before birth
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• most homozygotes die within 24 hours of birth
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• most mutant mice exhibit early postnatal lethality
• about 10% of homozygotes survive beyond weaning; these do not exhibit cleft palate nor intestinal abnormalities
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behavior/neurological
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• suggested by empty stomachs
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respiratory system
homeostasis/metabolism
craniofacial
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• observed in those mice that die early
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digestive/alimentary system
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• suggested by empty stomachs
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• observed in those mice that die early
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• inflated abdomen due to air bubbles in the gastrointestinal tract
• markedly shortened intestine with coagulated blood
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• inflated abdomen with massive air bubbles in the gastrointestinal tract
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skeleton
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• ossified parts of the humerus are shorter than normal
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• defective endochondral bone ossification
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• ossification of membranous bone in the cranium partially impaired
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growth/size/body
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• observed in those mice that die early
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• inflated abdomen with massive air bubbles in the gastrointestinal tract
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• 1/4 to 1/2 normal body weight
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reproductive system
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• increased numbers of atretic follicles
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• immature at 5 weeks of age
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• fluid in uterus at 5 months of age
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• vaginal atresia at 5 months of age
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• immature at 5 weeks of age
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• immature at 5 weeks of age
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• immature at 5 weeks of age
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• delayed sexual maturation in males
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embryo
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• reduced invasion of giant cells
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• increased proliferation of spongiotrophoblasts
(J:102344)
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• increased proliferation of labyrinthine trophoblasts
(J:102344)
• reduced labyrinthine space
(J:102344)
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• 140mg at E17.5 compared to 110mg for controls
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immune system
endocrine/exocrine glands
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• immature at 5 weeks of age
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• immature at 5 weeks of age
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• increased numbers of atretic follicles
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• immature at 5 weeks of age
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limbs/digits/tail
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• ossified parts of the humerus are shorter than normal
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hematopoietic system
Allelic
Composition |
Cdkn1ctm1Kat/Cdkn1c+
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Genetic
Background |
involves: 129P2/OlaHsd |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm1Kat mutation
(1 available);
any
Cdkn1c mutation
(19 available)
|
|
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renal/urinary system
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• when this allele is maternally inherited, protein secretion is 2.8 times greater by day 17.5 of pregnancy than in pregnant wild-type mice
• however, protein secretion is normal after delivery or when this allele is inherited parentally
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• when this allele is maternally inherited, glomeruli are enlarged and irregularly shaped with increased subendothelial and mesangial depositions in glomeruli capillaries by day 17.5 of pregnancy unlike in pregnant wild-type mice
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• when this allele is maternally inherited, some pregnant mice exhibit nephrosclerosis unlike pregnant wild-type mice
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• when this allele is maternally inherited, fibroid and hyaline deposits are observed in the proximal and distal tubules of pregnant mice unlike in pregnant wild-type mice
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embryo
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• when this allele is maternally inherited, fewer giant cells invade to maternal vessels at the maternal-fetal interface compared to in wild-type mice
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• when this allele is maternally inherited, the labyrinthine space is narrow unlike in wild-type mice due to increased proliferation of spongio- and labyrinthine trophoblasts
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• when this allele is maternally inherited
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cardiovascular system
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• when this allele is maternally inherited, systolic blood pressure increases at E9.5 through delivery before retuning to normal unlike pregnant wild-type mice that maintain normal blood pressure throughout pregnancy
• however, blood pressure is normal after delivery or when this allele is inherited parentally
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hematopoietic system
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• when this allele is maternally inherited, platelet counts are decreased to 55% of counts in pregnant wild-type by day 17 of pregnancy
• however, platelet counts are normal when this allele is inherited parentally
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homeostasis/metabolism
Allelic
Composition |
Cdkn1ctm1Kat/Cdkn1c+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm1Kat mutation
(1 available);
any
Cdkn1c mutation
(19 available)
|
|
|
mortality/aging
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• slight lethality before birth
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• about half of heterozygotes die within 24 hours of birth
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behavior/neurological
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• in about half of heterozygotes
• suggested by empty stomachs
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respiratory system
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• in about half of heterozygotes
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homeostasis/metabolism
craniofacial
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• observed in those mice that die early
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digestive/alimentary system
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• in about half of heterozygotes
• suggested by empty stomachs
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• observed in those mice that die early
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• various intestinal abnormalities in those mice that die early
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reproductive system
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• birth 2 days early, after 18 days
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hematopoietic system
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• in females during pregnancy, by 48-55%
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cardiovascular system
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• blood pressure rises during pregnancy
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renal/urinary system
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• increases greatly in females during pregnancy
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• endotheliosis leading to nephrosclerosis in pregnant females
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• enlarged in pregnant females at E17.5
• also irregularly shaped
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cellular
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• paternal allele is transcriptionally repressed
• no abnormal phenotype in crosses between heterozygous males and wild-type females
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growth/size/body
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• observed in those mice that die early
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Allelic
Composition |
Cdkn1ctm1Kat/Cdkn1c+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm1Kat mutation
(1 available);
any
Cdkn1c mutation
(19 available)
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Small size of Cdkn1ctm1Kat/Cdkn1c+ mice at 7 weeks of age
mortality/aging
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• most mice die shortly after birth although some survive to weaning
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cellular
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• all mice carry a maternally inherited mutant allele
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embryo
growth/size/body
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• thinning of the abdominal wall or omphalocele are seen
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• thinning of the abdominal wall or omphalocele are seen
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• seen in mice that survive to weaning
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renal/urinary system
digestive/alimentary system
endocrine/exocrine glands
vision/eye
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• increased cell proliferation is seen in the lens at E13.5
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reproductive system
skeleton
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• increased cell proliferation is seen in the zones of proliferation and flattened cells in the humerus at E16.5
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• of the occipital bone, digits, and long bones
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craniofacial
Analysis Tools