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Phenotypes Associated with This Genotype
Genotype
MGI:3838163
Allelic
Composition
Cdkn1ctm1Kat/Cdkn1c+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1ctm1Kat mutation (1 available); any Cdkn1c mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• when this allele is maternally inherited, protein secretion is 2.8 times greater by day 17.5 of pregnancy than in pregnant wild-type mice
• however, protein secretion is normal after delivery or when this allele is inherited parentally
• when this allele is maternally inherited, glomeruli are enlarged and irregularly shaped with increased subendothelial and mesangial depositions in glomeruli capillaries by day 17.5 of pregnancy unlike in pregnant wild-type mice
• when this allele is maternally inherited, some pregnant mice exhibit nephrosclerosis unlike pregnant wild-type mice
• when this allele is maternally inherited, fibroid and hyaline deposits are observed in the proximal and distal tubules of pregnant mice unlike in pregnant wild-type mice

embryo
• when this allele is maternally inherited, fewer giant cells invade to maternal vessels at the maternal-fetal interface compared to in wild-type mice
• when this allele is maternally inherited, the labyrinthine space is narrow unlike in wild-type mice due to increased proliferation of spongio- and labyrinthine trophoblasts
• when this allele is maternally inherited

cardiovascular system
• when this allele is maternally inherited, systolic blood pressure increases at E9.5 through delivery before retuning to normal unlike pregnant wild-type mice that maintain normal blood pressure throughout pregnancy
• however, blood pressure is normal after delivery or when this allele is inherited parentally

hematopoietic system
• when this allele is maternally inherited, platelet counts are decreased to 55% of counts in pregnant wild-type by day 17 of pregnancy
• however, platelet counts are normal when this allele is inherited parentally

homeostasis/metabolism
• when this allele is maternally inherited, protein secretion is 2.8 times greater by day 17.5 of pregnancy than in pregnant wild-type mice
• however, protein secretion is normal after delivery or when this allele is inherited parentally

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pre-eclampsia DOID:10591 OMIM:189800
OMIM:609402
OMIM:609403
OMIM:609404
OMIM:614592
J:102331


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory