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Phenotypes Associated with This Genotype
Genotype
MGI:3576657
Allelic
Composition
Ptgs1tm1Fun/Ptgs1tm1Fun
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptgs1tm1Fun mutation (1 available); any Ptgs1 mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in response to arachidonic acid and capsaicin in an ear swelling assay or carrageenan treatment in a paw edema assay
• no inflammatory protection was observed with tetradecanoyl phorbol acetate (TPA) and croton oil induced inflammation

hematopoietic system
• in ex vivo, platelets did not aggregate in response to concentrations of arachidonic acid that were effective in wild-type platelets

reproductive system
N
• normal gestational length, normal parturition, normal litter size and development, normal ovaries size and weight

homeostasis/metabolism
• in ex vivo, platelets did not aggregate in response to concentrations of arachidonic acid that were effective in wild-type platelets
• mice were resistant to arachidonic acid induced thrombosis in vivo
• tail bleeding time was significantly prolonged
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2
• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

renal/urinary system
• significantly reduced urinary excretion of 11alpha-hydroxy-9,15-dioxo-2,3,4,5-tetranor-prostane-1,20 dioic acid
• significantly reduced urinary excretion of 1,3-dinor-thromboxane B2

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pre-eclampsia DOID:10591 OMIM:189800
OMIM:609402
OMIM:609403
OMIM:609404
OMIM:614592
J:97351


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory