Phenotypes Associated with This Genotype

Genotype
MGI:7435433

• Allelic Composition: Kras^tm4Tyj/Kras⁺; Tg(Slco1c1-icre/ERT2)1Mrks/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal brain vasculature morphology ( J:312482 )

• vasculature surrounding brain arteriovenous malformations is abnormal in tamoxifen-administered mice, with vessels appearing tortuous and dilated, similar to niduses associated with these lesions in human patients

arteriovenous malformation ( J:312482 )

• mice administered tamoxifen at P1 show presence of brain arteriovenous malformations at 8 weeks of age occurring in the cortex, just anterior to the cerebellum, as well as near the olfactory bulb

intracranial hemorrhage ( J:312482 )

• mice administered tamoxifen at P1 only rarely show intracranial hemorrhage (1 of 28 mice) at 8 weeks of age

nervous system

abnormal brain vasculature morphology ( J:312482 )

• vasculature surrounding brain arteriovenous malformations is abnormal in tamoxifen-administered mice, with vessels appearing tortuous and dilated, similar to niduses associated with these lesions in human patients

intracranial hemorrhage ( J:312482 )

• mice administered tamoxifen at P1 only rarely show intracranial hemorrhage (1 of 28 mice) at 8 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
arteriovenous malformations of the brain		DOID:0060688	OMIM:108010	J:312482