Phenotypes Associated with This Genotype

Genotype
MGI:3622096

• Allelic Composition: Abcc9^tm1Cfb/Abcc9^tm1Cfb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:78066 )

• by 30 weeks of age, 65% of males and 35% of females die suddenly

cardiovascular system

artery stenosis ( J:78066 )

abnormal ST segment ( J:78066 )

• exhibit repeated episodes of spontaneous ST segment elevation that are often followed by slow heart rate, however show normal baseline resting heart rate, PR intervals and QRS

• ST segment depression is seen during the recovery phase of the transient ischemic events

abnormal systemic arterial blood pressure ( J:78066 )

• do not show a drop in blood pressure with pinacidil administration or any response to glyburide as in wild-type

hypertension ( J:78066 )

increased systemic arterial diastolic blood pressure ( J:78066 )

• seen in conscious 12- to 18-week old mice

increased systemic arterial systolic blood pressure ( J:78066 )

• seen in conscious 12- to 18-week old mice

abnormal vascular smooth muscle physiology ( J:78066 )

• glibenclamide-sensitive K_ATP current is absent in aortic smooth muscle cells

coronary artery spasm ( J:78066 )

• exhibit transient, repeated episodes of coronary artery vasospasm

• calcium channel antagonists reduce coronary artery vasospasms

muscle

abnormal vascular smooth muscle physiology ( J:78066 )

• glibenclamide-sensitive K_ATP current is absent in aortic smooth muscle cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
coronary artery disease		DOID:3393	OMIM:300464 OMIM:607339 OMIM:608316 OMIM:608318 OMIM:608320 OMIM:610947 OMIM:611139 OMIM:612030 OMIM:614293	J:78066