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Phenotypes Associated with This Genotype
Genotype
MGI:5703970
Allelic
Composition
Asb4tm1.2Cpat/Asb4tm1.2Cpat
Genetic
Background
involves: 129/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Asb4tm1.2Cpat mutation (0 available); any Asb4 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• fetal growth of some embryos is halted at E10.5-E11.5
• fewer mature endothelial-like cells in the placenta at E17.5
• trophoblast stem cells do not differentiate in culture into trophoblast giant cells
• invasion of the fetal component of the placenta into the maternal decidual layers is more shallow than in controls

reproductive system
• females deliver prematurely at 19.5 dpc
• females provided with nicotinamide in their drinking water show prolonged pregnancies and deliver pups at 20.5 dpc
• smaller litters produced due to mid-gestation spontaneous abortion (J:213825)
• fewer homozygotes produced from heterozygote matings (J:213825)
• dams have about half the number of live fetuses at 18.5 dpc than wild-type dams (J:238841)
• nicotinamide treatment of dams prevents loss of embryos (J:238841)

cardiovascular system
• pregnant females exhibit endotheliosis as indicated by a decrease in the open capillary areas of the renal glomeruli of dams
• treatment with nicotinamide prevents endotheliois
• fewer mature endothelial-like cells in the placenta at E17.5
• increased blood pressures in pregnant females from E14 to term
• females exhibit hypertension by the third week of pregnancy
• treatment with nicotinamide prevents the increase in systolic blood pressure in pregnant females

renal/urinary system
• pregnant females exhibit endotheliosis as indicated by a decrease in the open capillary areas of the renal glomeruli of dams
• treatment with nicotinamide prevents endotheliois
• increased albumin:creatinine ratios in the urine of pregnant females at late stages of pregnancy
• females develop albuminuria by the 3rd week of pregnancy
• treatment with nicotinamide prevents the development of albuminuria in pregnant females
• pregnant females exhibit mesangial expansion as indicated by an increase in PAS-positive area in glomeruli
• treatment with nicotinamide prevents mesangial expansion

homeostasis/metabolism
• increased albumin:creatinine ratios in the urine of pregnant females at late stages of pregnancy
• females develop albuminuria by the 3rd week of pregnancy
• treatment with nicotinamide prevents the development of albuminuria in pregnant females

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pre-eclampsia DOID:10591 OMIM:189800
OMIM:609402
OMIM:609403
OMIM:609404
OMIM:614592
J:238841


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory