Rbpj^tm1Kyo
Targeted Allele Detail

Summary

• Symbol: Rbpj^tm1Kyo
• Name: recombination signal binding protein for immunoglobulin kappa J region; targeted mutation 1, Kyoto University
• MGI ID: MGI:1857411
• Synonyms: RBPjk-, RBP-Jkappa-
• Gene: Rbpj Location: Chr5:53713121-53814787 bp, + strand Genetic Position: Chr5, 29.37 cM, cytoband C1-C3
• Alliance: Rbpj^tm1Kyo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29277
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 7 was disrupted by the insertion of a neomycin selection cassette. Western blot analysis indicated that protein was not produced from the targeted allele. (J:29277)

Disease models

Expression

In Mice Carrying this Mutation:	75 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rbpj Mutation: 193 strains or lines available

References

• Original: J:29277 Oka C, et al., Disruption of the mouse RBP-J kappa gene results in early embryonic death. Development. 1995 Oct;121(10):3291-301
• All: 33 reference(s)