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Targeted Allele Detail
Symbol: Elntm1Dyl
Name: elastin; targeted mutation 1, Dean Y Li
MGI ID: MGI:2153007
Synonyms: Eln-
Gene: Eln  Location: Chr5:134731447-134776177 bp, - strand  Genetic Position: Chr5, 74.76 cM
Alliance: Elntm1Dyl page
Reduced vessel extensibility in the Fbln5tm1Eno/Fbln5tm1Eno and Elntm1Dyl/Eln+ carotid artery

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:47771
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced 4kb of gene sequence. In situ hybridization analysis showed the absence of the transcript in aortae of E17.5 homozygous mutant mice. The protein was not detectable in P0.5 aortae of homozygous mutant mice by hart staining. (J:47771)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Eln Mutation:  18 strains or lines available
Original:  J:47771 Li DY, et al., Elastin is an essential determinant of arterial morphogenesis. Nature. 1998 May 21;393(6682):276-80
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory