Krit1^tm1Kwhi
Targeted Allele Detail

Summary

• Symbol: Krit1^tm1Kwhi
• Name: KRIT1, ankyrin repeat containing; targeted mutation 1, Kevin Whitehead
• MGI ID: MGI:5532525
• Synonyms: CCM1^fl, Ccm1^flox
• Gene: Krit1 Location: Chr5:3853156-3894515 bp, + strand Genetic Position: Chr5, 2.26 cM
• Alliance: Krit1^tm1Kwhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215458
• Parent Cell Line: G4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NCrl)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 4-8 were floxed. (J:215458)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Krit1 Mutation: 34 strains or lines available

References

• Original: J:215458 Mleynek TM, et al., Lack of CCM1 induces hypersprouting and impairs response to flow. Hum Mol Genet. 2014 Dec 1;23(23):6223-34
• All: 11 reference(s)